Hey guys!

I thought about Lorelei Martins and to me she seems as if she really likes Jane.
Furthermore she is clever and I'm sure subconsciously she knows that what red John does isn't good and feels sorry for what he did to Jane.
Since she's part of Red John's doings she's a bad conscience to Jane. 
So she gives him a hint: the "shaking hands" thing.
Not by mistake, but with purpose, because she doesn't react as if she revealed something she didn't want to say.
What if she told him exactly who Red John is in that sentence?
"I'm surprised you didn't become lifelong friends from the moment you shook hands"
Well, maybe she means that ironically?
And tells him with this that maybe his best friend (Lisbon) is Red John, because actually they became kind of lifelong friends after they shook hands.