Why did The Blake Association suddenly turn on one of their own:  Agent Reede Smith?  It is because of them that he turned to CBI to help him.
We know Bertram is creating diversions to keep CBI busy and off of him so you would think he would want Smith out there running around and keeping CBI busy.
My guess is that Reede Smith has info about Red John he doesn't realize he has and/or Kirkland's twin found out Smith killed his brother without permission so he is being punished.
These questions coincide with my previous post:"Did anyone else notice these strange interactions between Grace Van Pelt and Reede Smith?
First - As we have seen in the past, Grace is an Ace shooter so surprised she didn't at least nick Smith.
Second - Not only did she let him escape but she didn't even run after him or get in car and chase him down.  That's not like her.
Third, Reede Smith called in to Van Pelt's direct line from a burner phone AND she automatically recognized his voice when he asked for help.  Since the advent of Caller ID and Cell phones, don't think she would have known it was him via Caller ID since burner phones have no name associated with them unless she recognized his phone number since she could have called or received a call from him before from that number of his burner phone.  Even more interesting, thanks to cell phone contact lists, hardly any of us know phone numbers off the top of our head unless it is a phone number we have known for a very long time or one we have to dial frequently and Smith went from dialing to speaking directly with her.
We know from Van Pelt wearing a strapless wedding dress there are no Red Dot Tattoos on her arm/shoulder but there is, as many have said, something just not right."